The lymphatic vasculature revisited-new developments in the zebrafish.
Identifieur interne : 000094 ( Main/Exploration ); précédent : 000093; suivant : 000095The lymphatic vasculature revisited-new developments in the zebrafish.
Auteurs : Y. Padberg [Allemagne] ; S. Schulte-Merker [Allemagne] ; A. Van Impel [Allemagne]Source :
- Methods in cell biology [ 0091-679X ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Cellules endothéliales (anatomopathologie), Cellules endothéliales (ultrastructure), Danio zébré (physiologie), Humains, Imagerie moléculaire (), Lymphangiogenèse, Lymphoedème (imagerie diagnostique), Lymphoedème (physiopathologie), Modèles animaux de maladie humaine, Obésité (imagerie diagnostique), Obésité (physiopathologie), Polyarthrite rhumatoïde (imagerie diagnostique), Polyarthrite rhumatoïde (physiopathologie), Vaisseaux lymphatiques (imagerie diagnostique), Vaisseaux lymphatiques (physiopathologie).
- MESH :
- anatomopathologie : Cellules endothéliales.
- imagerie diagnostique : Lymphoedème, Obésité, Polyarthrite rhumatoïde, Vaisseaux lymphatiques.
- physiologie : Danio zébré.
- physiopathologie : Lymphoedème, Obésité, Polyarthrite rhumatoïde, Vaisseaux lymphatiques.
- Animaux, Cellules endothéliales, Humains, Imagerie moléculaire, Lymphangiogenèse, Modèles animaux de maladie humaine.
English descriptors
- KwdEn :
- Animals, Arthritis, Rheumatoid (diagnostic imaging), Arthritis, Rheumatoid (physiopathology), Disease Models, Animal, Endothelial Cells (pathology), Endothelial Cells (ultrastructure), Humans, Lymphangiogenesis, Lymphatic Vessels (diagnostic imaging), Lymphatic Vessels (physiopathology), Lymphedema (diagnostic imaging), Lymphedema (physiopathology), Molecular Imaging (methods), Obesity (diagnostic imaging), Obesity (physiopathology), Zebrafish (physiology).
- MESH :
- diagnostic imaging : Arthritis, Rheumatoid, Lymphatic Vessels, Lymphedema, Obesity.
- methods : Molecular Imaging.
- pathology : Endothelial Cells.
- physiology : Zebrafish.
- physiopathology : Arthritis, Rheumatoid, Lymphatic Vessels, Lymphedema, Obesity.
- ultrastructure : Endothelial Cells.
- Animals, Disease Models, Animal, Humans, Lymphangiogenesis.
Abstract
The lymphatic system is lined by endothelial cells and part of the vasculature. It is essential for tissue fluid homeostasis, absorption of dietary fats, and immune surveillance in vertebrates. Misregulation of lymphatic vessel formation and dysfunction of the lymphatic system have been indicated in a number of pathological conditions including lymphedema formation, obesity or chronic inflammatory diseases such as rheumatoid arthritis. In zebrafish, lymphatics were discovered about 10years ago, and the underlying molecular pathways involved in its development have since been studied in detail. Due to its superior live cell imaging possibilities and the broad tool kit for forward and reverse genetics, the zebrafish has become an important model organism to study the development of the lymphatic system during early embryonic development. In the current review, we will focus on the key players during zebrafish lymphangiogenesis and compare the roles of these genes to their mammalian counterparts. In particular, we will focus on novel findings that shed new light on the molecular mechanisms of lymphatic cell fate specification, as well as sprouting and migration of lymphatic precursor cells.
DOI: 10.1016/bs.mcb.2016.11.001
PubMed: 28129845
Affiliations:
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Le document en format XML
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Van Impel</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC M 1003-CiM), University of Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC M 1003-CiM), University of Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author></analytic><series><title level="j">Methods in cell biology</title><idno type="ISSN">0091-679X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Arthritis, Rheumatoid (diagnostic imaging)</term><term>Arthritis, Rheumatoid (physiopathology)</term><term>Disease Models, Animal</term><term>Endothelial Cells (pathology)</term><term>Endothelial Cells (ultrastructure)</term><term>Humans</term><term>Lymphangiogenesis</term><term>Lymphatic Vessels (diagnostic imaging)</term><term>Lymphatic Vessels (physiopathology)</term><term>Lymphedema (diagnostic imaging)</term><term>Lymphedema (physiopathology)</term><term>Molecular Imaging (methods)</term><term>Obesity (diagnostic imaging)</term><term>Obesity (physiopathology)</term><term>Zebrafish (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules endothéliales (anatomopathologie)</term><term>Cellules endothéliales (ultrastructure)</term><term>Danio zébré (physiologie)</term><term>Humains</term><term>Imagerie moléculaire ()</term><term>Lymphangiogenèse</term><term>Lymphoedème (imagerie diagnostique)</term><term>Lymphoedème (physiopathologie)</term><term>Modèles animaux de maladie humaine</term><term>Obésité (imagerie diagnostique)</term><term>Obésité (physiopathologie)</term><term>Polyarthrite rhumatoïde (imagerie diagnostique)</term><term>Polyarthrite rhumatoïde (physiopathologie)</term><term>Vaisseaux lymphatiques (imagerie diagnostique)</term><term>Vaisseaux lymphatiques (physiopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules endothéliales</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Lymphoedème</term><term>Obésité</term><term>Polyarthrite rhumatoïde</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Danio zébré</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Zebrafish</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Obésité</term><term>Polyarthrite rhumatoïde</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules endothéliales</term><term>Humains</term><term>Imagerie moléculaire</term><term>Lymphangiogenèse</term><term>Modèles animaux de maladie humaine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic system is lined by endothelial cells and part of the vasculature. It is essential for tissue fluid homeostasis, absorption of dietary fats, and immune surveillance in vertebrates. Misregulation of lymphatic vessel formation and dysfunction of the lymphatic system have been indicated in a number of pathological conditions including lymphedema formation, obesity or chronic inflammatory diseases such as rheumatoid arthritis. In zebrafish, lymphatics were discovered about 10years ago, and the underlying molecular pathways involved in its development have since been studied in detail. Due to its superior live cell imaging possibilities and the broad tool kit for forward and reverse genetics, the zebrafish has become an important model organism to study the development of the lymphatic system during early embryonic development. In the current review, we will focus on the key players during zebrafish lymphangiogenesis and compare the roles of these genes to their mammalian counterparts. In particular, we will focus on novel findings that shed new light on the molecular mechanisms of lymphatic cell fate specification, as well as sprouting and migration of lymphatic precursor cells.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Münster</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Münster</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Padberg, Y" sort="Padberg, Y" uniqKey="Padberg Y" first="Y" last="Padberg">Y. Padberg</name></region><name sortKey="Schulte Merker, S" sort="Schulte Merker, S" uniqKey="Schulte Merker S" first="S" last="Schulte-Merker">S. Schulte-Merker</name><name sortKey="Van Impel, A" sort="Van Impel, A" uniqKey="Van Impel A" first="A" last="Van Impel">A. Van Impel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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